Coumarins and derivatives
Apexbio Technology LLC Dicoumarol 66-76-2 100mg
Dicoumarol (CAS 66-76-2) is a small molecule inhibitor targeting NAD(P)H quinone oxidoreductase 1 (NQO1) and pyruvate dehydrogenase kinase 1 (PDK1) exhibiting IC50 values of 0 37 M and 19 42 M respectively in vitro By inhibiting NQO1 Dicoumarol perturbs cellular redox homeostasis while its suppression of PDK1 modulates glycolytic flux and mitochondrial energy metabolism These actions make Dicoumarol a valuable tool for investigating tumor metabolism oxidative stress apoptosis and associated signaling pathways in biomedical research contexts
Cayman Chemical 3-Cyno-7-ethoxycoumarIn 25mg
A fluorogenic CYP450 substrate; a substrate for CYP1A1 and CYP1A2; metabolized to a lesser extent by CYP2D6 and CYP2C19; metabolized to 3-cyano-7-hydroxycoumarin and its fluorescence can be used to quantify CYP450 isoform activity
Medchemexpress LLC HY-D0981 100mg Medchemexpress, 7-Amino-4-(trifluoromethyl)coumarin CAS:53518-15-3 Purity:>98%
Medchemexpress, HY-D0981 100mg 7-Amino-4-(trifluoromethyl)coumarin CAS:53518-15-3 7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) is a fluorescent marker for the sensitive detection of proteinases. The excitation and emission wavelengths are 400 and 490 nm, respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC 4-Methoxycoumarin | 20280-81-3 | 176.17 g/mol | C10H8O3 | 1 G
4-Methoxycoumarin is a coumarin derivative used in research with reported antibacterial activity against Ralstonia solanacearum. It is supplied as a powder with chemical formula C10H8O3 (molecular weight 176.17 g/mol) and CAS number 20280-81-3. The compound is soluble in DMSO (100 mg/mL; ultrasonic assistance recommended), and storage guidance and solution stability are provided for laboratory handling.
- Antibacterial activity against Ralstonia solanacearum
- Chemical formula C10H8O3 and molecular weight 176.17 g/mol
- CAS number 20280-81-3 for unambiguous identification
- High DMSO solubility: 100 mg/mL (requires ultrasonic)
- Storage stability: powder -20°C (up to 3 years), 4°C (up to 2 years); in solvent -80°C (6 months), -20°C (1 month)
- Solution preparation guidance from 1 g: 1 mM = 5.6763 mL, 5 mM = 1.1353 mL, 10 mM = 0.5676 mL
Apexbio Technology LLC 7-Amino-4-(trifluoromethyl)coumarin 53518-15-3 500mg
7-Amino-4-trifluoromethyl coumarin (CAS 53518-15-3) is a small-molecule antagonist targeting serotonin receptor subtype 1E (HTR1E) galanin receptor 2 (GALR2) and gamma receptor subtype 2 (GalR2) It is designed to antagonize these receptors thereby modulating receptor-mediated signaling pathways 7-Amino-4-trifluoromethyl coumarin exerts its biological activity primarily through receptor antagonism and inhibition of hydroxysteroid 17-beta dehydrogenase 4 (HSD17B4) enzymatic activity In biochemical assays it demonstrates inhibitory activity toward HSD17B4 with reported bioactivity at approximately 21 M Based on these pharmacological properties 7-Amino-4-trifluoromethyl coumarin holds research potential in the investigation of protease activity receptor-mediated signaling and metabolic enzyme regulation
Apexbio Technology LLC Coumarin-3-carboxylic Acid 531-81-7 100mg
Coumarin-3-carboxylic Acid is a coumarin-derived small molecule commonly applied as an investigative tool in biomedical research focusing on signal pathway regulation It is utilized to modulate enzymatic activities and cellular signaling pathways Coumarin-3-carboxylic Acid s biological activity has been studied in the context of its lanthanide complexes for inhibitory effects on cell growth in K-562 cell lines In cell-based studies it demonstrates antiproliferative activity in K-562 cells Based on these pharmacological properties Coumarin-3-carboxylic Acid holds research potential in elucidating biological mechanisms underlying hematologic malignancies and related diseases
Cayman Chemical 4-HydroxycoumarIn 100g
A coumarin; inhibits vitamin K1 epoxidation and prothrombin synthesis by 18 and 67%, respectively, in cell-free assays at 6.2 mM; has been used in the synthesis of anticoagulants, as well as antithrombotic, anti-inflammatory, antibacterial, and antifungal agents
Medchemexpress LLC Daphnetin (7,8-dihydroxycoumarin) | 486-35-1 | 99.8% | 178.14 | 5 MG
Daphnetin (7,8-dihydroxycoumarin) is a coumarin derivative found in plants of the Genus Daphne. It is a potent, orally active protein kinase inhibitor.
- Has IC50s of 7.67 μM, 9.33 μM, and 25.01 μM for EGFR, PKA, and PKC in vitro, respectively.
- Triggers ROS-induced cell apoptosis.
- Induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway.
- Possesses anti-inflammatory activity, inhibiting TNF-α, IL-1β, ROS, and MDA production.
- Exhibits schizontocidal activity against malaria parasites.
- Can be utilized in research for rheumatoid arthritis, cancer, and anti-malarial purposes.
Medchemexpress LLC Esculetin | 305-01-1 | 99.79% | 178.14 | 1 ML
Esculetin is an active ingredient extracted mainly from the bark of *Fraxinus rhynchophylla*. It primarily functions by inhibiting the PI3K/Akt pathway, which affects platelet-derived growth factor (PDGF)-induced airway smooth muscle cells (ASMCs) phenotype switching. Additionally, Esculetin demonstrates antioxidant, anti-inflammatory, and antitumor properties, making it a subject of various research applications. It is intended for research use only and not for medical or patient use.
- Inhibits platelet-derived growth factor (PDGF)-induced airway smooth muscle cell (ASMC) proliferation and migration.
- Demonstrates antioxidant activity.
- Exhibits anti-inflammatory effects.
- Possesses antitumor activities.
- Targets PI3K pathway.
- Induces apoptosis in certain cancer cell types.
- Ameliorates skin lesions in psoriatic mice models.
eMolecules 136705-71-0 | Ambeed | 12-Bis((2R5R)-25-diethylphospholano)ethane(cyclooctadiene)rhodium(I) trifluoromethanesulfonate | 50mg | 650569995 | A1228631 | 670.55 | C27H44F3O3P2RhS
Ambeed | (R)-3-Hydroxy-2-phenylpropanoic acid | 100mg | 600846987 | A749272 | 17126-67-9 | MFCD00211261 | 166.176 | C9H10O3
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