Coumarins and derivatives
Medchemexpress LLC 3-Hydroxycoumarin | 939-19-5 | 99.3% | 100 MG
3-Hydroxycoumarin is an inhibitor of tyrosinase and lipoxygenase. It exhibits photoprotective effects on sea urchin zygotes and embryos, and also demonstrates free radical scavenging activities.
- Inhibits tyrosinase (IC50 for recombinant human tyrosinase of 26 μM) and lipoxygenase (IC50 for LOX of 9.5 μM).
- Displays DPPH free radical scavenging activity (IC50 = 31.2 μM).
- Provides photoprotective effects on sea urchin zygotes and embryos.
- Can be formulated into a vesicle delivery system for efficient local accumulation in the skin.
Medchemexpress LLC 7-methoxycoumarin-3-carboxylic acid | 20300-59-8 | MFCD00452770 | 97.0% | 220.18 g/mol | C11H8O5 | 500 MG
7-Methoxycoumarin-3-carboxylic acid is a coumarin-based fluorescent dye used to label peptides and small biomolecules. It exhibits ultraviolet excitation and blue emission, making it suitable for fluorescence assays, probe synthesis, and HPLC derivatization. The compound is supplied as a solid and should be handled and stored protected from light.
Medchemexpress LLC 7-methoxycoumarin-3-carboxylic acid | 20300-59-8 | MFCD00452770 | 97.0% | 220.18 g·mol⁻¹ | C11H8O5 | 5 G
7-methoxycoumarin-3-carboxylic acid is a coumarin-derived fluorescent dye (CAS 20300-59-8) commonly used to label peptides and amines and for HPLC derivatization. It is a white to off-white solid (C11H8O5, MW 220.18 g·mol⁻¹) that exhibits blue fluorescence; optical properties are solvent- and pH-dependent and should be validated for the intended assay.
- Fluorescent label suitable for peptide and amine conjugation.
- Useful for HPLC derivatization and fluorescent detection.
- Blue fluorescence with excitation and emission peaks that vary by solvent and pH.
- Available as a solid, white to off-white powder for easy handling.
- Well-characterized chemical identity and molecular weight for reproducible results.
Apexbio Technology LLC 3-Carboxy-7-Hydroxycoumarin 779-27-1 1g
3-Carboxy-7-Hydroxycoumarin (CAS 779-27-1) is a coumarin-based fluorescent molecule It is characterized by blue fluorescence emission upon excitation with ultraviolet light Structurally it features a carboxyl group that enables conjugation via carbodiimide activation (e g EDAC-mediated formation of succinimidyl ester intermediates) allowing covalent attachment to amine-containing residues in proteins and nucleic acids Based on these properties 3-Carboxy-7-Hydroxycoumarin is commonly employed in biochemical research for fluorescent labeling including analysis of protein protein interactions nucleic acid visualization and biomolecule detection assays
Apexbio Technology LLC 3-Carboxy-7-Hydroxycoumarin 779-27-1 250mg
3-Carboxy-7-Hydroxycoumarin (CAS 779-27-1) is a coumarin-based fluorescent molecule It is characterized by blue fluorescence emission upon excitation with ultraviolet light Structurally it features a carboxyl group that enables conjugation via carbodiimide activation (e g EDAC-mediated formation of succinimidyl ester intermediates) allowing covalent attachment to amine-containing residues in proteins and nucleic acids Based on these properties 3-Carboxy-7-Hydroxycoumarin is commonly employed in biochemical research for fluorescent labeling including analysis of protein protein interactions nucleic acid visualization and biomolecule detection assays
Apexbio Technology LLC Esculin 531-75-9 20mg
Esculin (CAS 531-75-9) is a coumarin glucoside isolated from the bark of Aesculus hippocastanum It functions primarily as a -glucosidase substrate hydrolyzing to esculetin and glucose upon enzymatic action Esculin s fluorescence properties make it valuable in assays monitoring -glucosidase activity in microbiological and biochemical research Additionally its antioxidant and vasoprotective effects have supported investigations into microcirculatory disorders and oxidative stress-related models Esculin is soluble in hot ethanol methanol pyridine ethyl acetate and acetic acid and should be stored in sealed cool and dry conditions
Apexbio Technology LLC HX 531 188844-34-0 10mg
HX 531 (CAS 188844-34-0) is a small-molecule antagonist targeting the retinoid X receptor (RXR) It modulates RXR-associated signaling pathways thereby influencing both tumorigenic and metabolic biological processes HX 531 exerts its biological activity by antagonizing RXR which results in cell cycle arrest at the G0/G1 phase and modulation of leptin-dependent pathways and the p53-p21Cip1 signaling axis In rodent models HX 531 demonstrates an inhibitory activity with an IC50 value of approximately 18 nM Based on these pharmacological properties HX 531 holds research potential in the study of metabolic disorders obesity diabetes and cancer biology
Apexbio Technology LLC Coumarin 91-64-5 10mM (in 1mL DMSO)
Coumarin (91-64-5) is a small-molecule inhibitor targeting cytochrome P450 isoforms It is designed to modulate enzyme activity thereby regulating metabolic pathways Coumarin exerts its biological activity primarily through inhibition of cytochrome P450 enzymes In in vitro studies coumarin demonstrates enzyme inhibitory activity with an IC50 range of approximately 0 5 to 10 M depending on the isoform and experimental system Based on these pharmacological properties coumarin holds research potential in anticoagulant anti-inflammatory and anticancer agent discovery
Medchemexpress LLC 3-Acetylcoumarin | 3949-36-8 | 97.0% | 188.18 | 10 G
3-Acetylcoumarin is a light yellow to yellow solid known for its acaricidal activity. This compound is intended for research purposes and has demonstrated efficacy against Tetranychus cinnabarinus.
- Acaricidal activity against Tetranychus cinnabarinus.
- Intended for research use only.
Medchemexpress LLC Palomid 529 | 914913-88-5 | 99.4% | C24H22O6 | 50 MG
Palomid 529 | 914913-88-5 | 99.4% | C24H22O6 | 50 MG
Medchemexpress LLC 3-Acetylcoumarin | 3949-36-8 | 97.0% | 188.18 | 5 G
3-Acetylcoumarin (Compound 4) exhibits acaricidal activity against *Tetranychus cinnabarinus* and is intended for research use only. It has shown biological activity in various assays.
- Exhibits acaricidal activity against *Tetranychus cinnabarinus*
- IC50 of 14.45 μM for inhibition of human recombinant MAO-B
- IC50 of 75 μM for cytotoxicity against human SH-SY5Y cells
eMolecules 36651-81-7 | 5-Methyl-8-hydroxycoumarin | Synthonix - Stock | MFCD18450566 | 176.171 | C10H8O3 | 95.000 | Cc1ccc(O)c2oc(=O)ccc12 | 1g | 495880208
5-Methyl-8-hydroxycoumarin | Synthonix - Stock | 36651-81-7 | MFCD18450566 | 176.171 | C10H8O3 | 95.000 | Cc1ccc(O)c2oc(=O)ccc12 | 1g | 495880208
Cayman Chemical 4-HydroxycoumarIn 250g
A coumarin; inhibits vitamin K1 epoxidation and prothrombin synthesis by 18 and 67%, respectively, in cell-free assays at 6.2 mM; has been used in the synthesis of anticoagulants, as well as antithrombotic, anti-inflammatory, antibacterial, and antifungal agents
Indofine Chemical 7-Hydroxycoumarin, 99%, 250 Mg
Molecular Formula: C10H6O5, Purity >99%, Molecular Weight: 206.16, Melting Point >270C, Appearance: Cream colored powder, Solubility: Soluble in DMF, Storage conditions: Store in a cool, dry place, Also known as 3-Carboxy-7-hydroxycoumarin
AdipoGen Benzothiazolyl-2EtN coumarin
Chemical. CAS 38215-36-0. Formula C20H18N2O2S. MW 350.43. Synthetic. Fluorescent dye which is widely used for staining polymer particles, but also organelles or materials used in medicine.